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You can finish all the missions you did not finish, do the Challenges you did not accomplish and return the vault key to Tannis (she'll pay a large amount of cash for it), also check out Earl's scrapyard for a surprise. yes if you did the quest earls best friend the skag is all grown up
If you want to start a new game - exit your game then scroll to the save that you beat the game in then you will start a new play through were all the enemies are level up and harder to kill and at the end of the second playthrough you should be level 50 (maximum possible in Borderlands).
Also you can buy DLC content for Borderlands: Zombie Island of Dr.Ned, Mad Moxxxi's Underdome Riot and soon to be released The Secret Armory of General Knoxx.