Briefly stated, this is a minor glitch in the game, IMO. When I started my first character, the game responded in much the same way for me, too. It wouldn't open Zed's door. So I simply started that same character again, and had no problems since.
I have played through this game twice; the first character is up to Level 44. The second character is up to level 35, so I'm very familiar with this game.