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There are 2 playthroughs in which the quests are reset and you start over from the beginning. After you complete the game a 2nd time, the game does not reset in any fashion, but the next time you play the level of the enemies, in all locations, will be levels 48-51. Also the levels of the weapons found in all locations are level 48.

Officially 2 playthroughs, with what is called playthrough 2.5 after you are done with the 2nd playthrough.

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